E4F1

Across TCGA cell cohorts, E4F1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible E4F1-associated genes across cancer lineages are OR13H1, TMCO5A, and EPPIN. Each is linked with E4F1 in more than 1 cancer types. Because this analysis shows association rather than direction, both E4F1-to-partner and partner-to-E4F1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13H1 grouped by E4F1-low versus E4F1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E4F1→partner) and Y-score (partner→E4F1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR13H1 →	+0.082	+2.444	<.001	.008	3	2
SOFT_TISSUE	TMCO5A →	+0.115	+4.930	<.001	.008	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+5.507	<.001	<.001	3	1
BLOOD_Leukemia	HHLA1 →	+0.011	+4.551	<.001	.004	3	1
BLOOD_Leukemia	GPR26 →	+0.057	+4.539	<.001	.007	3	1
BLOOD_Leukemia	LYZL4 →	+0.080	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

OR13H1 by E4F1 expression — LARGE_INTESTINE

Explore this box plot interactively →