E2F8

Across TCGA patient cohorts, E2F8 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,825 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible E2F8-associated proteins across cancer lineages are SMC2, MCM5, and MCM6. Each is linked with E2F8 in more than 9 cancer types. Because this analysis shows association rather than direction, both E2F8-to-partner and partner-to-E2F8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F8 versus SMC2 in UCEC, with a Pearson correlation of 0.69.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F8→partner) and Y-score (partner→E2F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.766	+1.091	<.001	<.001	3	10
GBM	MCM5 →	+0.736	+0.791	<.001	<.001	3	10
GBM	MCM6 →	+0.787	+0.776	<.001	<.001	3	10
UCEC	NCAPD2 →	+0.722	+1.132	<.001	<.001	3	10
COAD	RRM1 →	+0.513	+0.795	<.001	<.001	3	9
LUAD	RRM2 →	+0.847	+0.985	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,825 associations by consensus.

E2F8 vs SMC2 — UCEC

Explore this scatter interactively →