E2F8

Across TCGA patient cohorts, E2F8 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F8-associated genes across cancer lineages are c-Met_pY1235, PCNA, and PDCD4. Each is linked with E2F8 in more than 3 cancer types. Because this analysis shows association rather than direction, both E2F8-to-partner and partner-to-E2F8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by E2F8-low versus E2F8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F8→partner) and Y-score (partner→E2F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met_pY1235 →	+0.096	+3.000	.010	.034	3	4
UCEC	PCNA →	+0.144	+1.652	.014	.005	3	4
UCEC	PDCD4 →	-0.407	-1.440	.001	.020	3	3
UCEC	ATM →	-0.351	-2.234	.004	.001	3	3
UCEC	Cyclin-D1 →	+0.149	+1.736	<.001	.005	3	3
BLCA	p27_pT198 →	+0.110	+2.841	.027	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

c-Met_pY1235 by E2F8 expression — SKCM

Explore this box plot interactively →