E2F8

Across TCGA cell cohorts, E2F8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,753 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible E2F8-associated GO terms across cancer lineages are Positive regulation of DNA-templated DNA replication, Negative regulation of cell cycle process, and DNA-templated DNA replication maintenance of fidelity. Each is linked with E2F8 in more than 19 cancer types. Because this analysis shows association rather than direction, both E2F8-to-partner and partner-to-E2F8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated DNA replication grouped by E2F8-low versus E2F8-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F8→partner) and Y-score (partner→E2F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of DNA-templated DNA replication →	+0.163	+1.319	<.001	<.001	3	20
BONE	Negative regulation of cell cycle process →	+0.089	+1.202	.005	.006	3	19
SOFT_TISSUE	DNA-templated DNA replication maintenance of fidelity →	+0.118	+1.679	<.001	<.001	3	19
OESOPHAGUS	Chorionic trophoblast cell differentiation →	+1.340	+1.523	<.001	<.001	3	19
BLOOD_Myeloma	DNA replication →	+0.107	+1.354	<.001	<.001	3	19
BONE	DNA replication initiation →	+0.189	+1.271	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,753 associations by consensus.

Positive regulation of DNA-templated DNA replication by E2F8 expression — LIVER

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