E2F8

Across TCGA cell cohorts, E2F8 mutation is significantly associated with the mutation status of many other genes, with 1,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F8-associated genes across cancer lineages are MYH9, INSRR, and TMEM131. Each is linked with E2F8 in more than 2 cancer types. Because this analysis shows association rather than direction, both E2F8-to-partner and partner-to-E2F8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH9 grouped by E2F8-low versus E2F8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F8→partner) and Y-score (partner→E2F8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MYH9 →	+3.339	+4.662	.003	.003	1	3
BLOOD_Leukemia	INSRR →	+3.145	+3.932	.004	.004	1	3
LARGE_INTESTINE	TMEM131 →	+2.574	+4.182	.003	.003	1	3
BLOOD_Leukemia	ZKSCAN3 →	+5.560	+4.736	.003	.003	1	3
BLOOD_Leukemia	DRD3 →	+5.560	+4.736	.003	.003	1	3
BLOOD_Leukemia	PTPN23 →	+2.560	+4.364	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

MYH9 by E2F8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →