Across TCGA pan-cancer cohorts, E2F6P3 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of E2F6P3’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where E2F6P3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types E2F6P3 is over-expressed in tumor.
BRCA are the cancer types where E2F6P3 tumor–normal differential expression is most reproducible.