E2F6

Across TCGA patient cohorts, E2F6 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,780 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E2F6-associated proteins across cancer lineages are PPM1G, PUM2, and ZNF638. Each is linked with E2F6 in more than 6 cancer types. Because this analysis shows association rather than direction, both E2F6-to-partner and partner-to-E2F6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F6 versus PPM1G in OV, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F6→partner) and Y-score (partner→E2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPM1G →	+0.428	+0.634	<.001	<.001	3	7
LSCC	PUM2 →	+0.328	+0.813	<.001	<.001	3	6
LSCC	ZNF638 →	+0.318	+0.769	<.001	<.001	3	6
LSCC	NOL11 →	+0.368	+0.646	<.001	<.001	3	6
LSCC	EFTUD2 →	+0.258	+0.660	<.001	<.001	3	6
GBM	MCM3 →	+0.690	+0.325	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,780 associations by consensus.

E2F6 vs PPM1G — OV

Explore this scatter interactively →