E2F6

Across TCGA patient cohorts, E2F6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,360 significant associations in total. GBM shows the largest number of these associations.

The most reproducible E2F6-associated genes across cancer lineages are KRBOX1, ARHGAP22, and TEFM. Each is linked with E2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F6-to-partner and partner-to-E2F6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, E2F6 versus KRBOX1 in UCEC, with a Pearson correlation of -0.97.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F6→partner) and Y-score (partner→E2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KRBOX1 →	-2.779	-0.504	.006	.008	3	2
GBM	ARHGAP22 →	+0.959	+0.438	.008	.007	3	2
GBM	TEFM →	-0.594	-0.418	.001	.007	3	2
GBM	ZFP2 →	-0.912	-0.458	.001	.008	3	2
GBM	POU5F2 →	-0.550	-0.473	.002	.004	3	2
UCEC	PRMT1 →	+1.674	+0.395	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,360 associations by consensus.

E2F6 vs KRBOX1 — UCEC

Explore this scatter interactively →