E2F6

Across TCGA patient cohorts, E2F6 mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F6-associated genes across cancer lineages are RNU1-80P, RNU6-1085P, and PGBD4P2. Each is linked with E2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F6-to-partner and partner-to-E2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-80P grouped by E2F6-low versus E2F6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F6→partner) and Y-score (partner→E2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU1-80P →	+0.217	+4.970	<.001	.005	3	2
UCEC	RNU6-1085P →	+0.339	+2.599	<.001	.009	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
COAD	NANOGNB →	+0.075	+5.942	<.001	<.001	3	1
COAD	TRDJ2 →	+1.021	+4.384	.001	.006	3	1
COAD	RPL23AP76 →	+0.094	+4.693	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

RNU1-80P by E2F6 expression — SKCM

Explore this box plot interactively →