E2F6

Across TCGA patient cohorts, E2F6 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F6-associated genes across cancer lineages are Endothelial cells, Erythrocytes, and Th2 cells. Each is linked with E2F6 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F6-to-partner and partner-to-E2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by E2F6-low versus E2F6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F6→partner) and Y-score (partner→E2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.042	-2.279	.028	.036	3	1
UCEC	Erythrocytes →	+0.035	+2.321	.004	.036	3	1
UCEC	Th2 cells →	+0.217	+2.321	.016	.036	3	1
UCEC	Basophils →	+0.272	+3.459	.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Endothelial cells by E2F6 expression — UCEC

Explore this box plot interactively →