E2F6

Across TCGA cell cohorts, E2F6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,776 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible E2F6-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Nuclear pore complex assembly, and Heterochromatin formation. Each is linked with E2F6 in more than 17 cancer types. Because this analysis shows association rather than direction, both E2F6-to-partner and partner-to-E2F6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by E2F6-low versus E2F6-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F6→partner) and Y-score (partner→E2F6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of gene expression, epigenetic →	+0.063	+0.502	.002	.003	3	18
UPPER_AERODIGESTIVE_TRACT	Nuclear pore complex assembly →	+0.141	+0.747	<.001	.003	3	17
OVARY	Heterochromatin formation →	+0.080	+0.767	<.001	<.001	3	16
BREAST	Regulation of centrosome cycle →	+0.070	+0.672	.002	.003	3	15
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.115	+0.899	<.001	<.001	3	15
OVARY	Heterochromatin organization →	+0.076	+0.810	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,776 associations by consensus.

Negative regulation of gene expression, epigenetic by E2F6 expression — STOMACH

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