E2F5

Across TCGA pan-cancer cohorts, E2F5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated E2F5 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher E2F5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated E2F5 expression acts as an unfavorable survival marker.

SKCM, COAD, and LGG are the cancer types where E2F5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	III,IV	0.232	0.708	.001	14	view →
COAD	OS	Median	All	0.168	0.806	.002	12	view →
LGG	DFS	Median	All	0.172	0.845	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

E2F5–SKCM (OS)

Open the SKCM breakdown →