E2F5

Across TCGA pan-cancer cohorts, E2F5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated E2F5 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher E2F5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated E2F5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and PDAC are the cancer types where E2F5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.904	0.485	.047	4	view →
LUAD	OS	Tertile	III,IV	1.000	0.845	.040	3	view →
PDAC	DFS	Median	IV	0.934	0.234	.017	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

E2F5–UCEC (DFS)

Open the UCEC breakdown →