E2F5

Across TCGA patient cohorts, E2F5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F5-associated genes across cancer lineages are p27_pT198, EGFR_pY1068, and A-Raf_pS299. Each is linked with E2F5 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F5-to-partner and partner-to-E2F5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by E2F5-low versus E2F5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F5→partner) and Y-score (partner→E2F5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.113	+2.807	.003	.003	3	2
UCEC	EGFR_pY1068 →	-0.219	-1.584	.015	.019	3	1
UCEC	A-Raf_pS299 →	-0.091	-1.700	.034	.042	3	1
UCEC	FASN →	+0.306	+3.321	.031	.009	3	1
UCEC	INPP4B →	-0.265	-2.584	.023	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.129	-1.807	.033	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

p27_pT198 by E2F5 expression — UCEC

Explore this box plot interactively →