E2F5

Across TCGA cell cohorts, E2F5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,661 significant associations in total. BONE shows the largest number of these associations.

The most reproducible E2F5-associated GO terms across cancer lineages are Negative regulation of protein localization to centrosome, snRNA metabolic process, and Mitochondrial DNA replication. Each is linked with E2F5 in more than 11 cancer types. Because this analysis shows association rather than direction, both E2F5-to-partner and partner-to-E2F5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to centrosome grouped by E2F5-low versus E2F5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F5→partner) and Y-score (partner→E2F5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of protein localization to centrosome →	+0.200	+1.359	<.001	.001	3	12
BONE	snRNA metabolic process →	+0.080	+1.972	<.001	<.001	3	11
OESOPHAGUS	Mitochondrial DNA replication →	+0.103	+1.211	.006	.002	3	10
BONE	Protein secretion →	-0.114	-2.097	<.001	.001	3	10
SOFT_TISSUE	Mitochondrial DNA metabolic process →	+0.128	+1.837	<.001	<.001	3	10
BONE	Positive regulation of monoatomic ion transport →	-0.147	-2.143	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,661 associations by consensus.

Negative regulation of protein localization to centrosome by E2F5 expression — OESOPHAGUS

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