E2F5

Across TCGA cell cohorts, E2F5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible E2F5-associated genes across cancer lineages are KLHL40, CST9, and MRGPRG. Each is linked with E2F5 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F5-to-partner and partner-to-E2F5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by E2F5-low versus E2F5-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F5→partner) and Y-score (partner→E2F5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CST9 →	+0.119	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRG →	+0.056	+5.209	<.001	.005	3	1
LARGE_INTESTINE	TMCO5A →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TMEM95 →	+0.025	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KLHL40 by E2F5 expression — BLOOD_Lymphoma

Explore this box plot interactively →