Across TCGA pan-cancer cohorts, E2F4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated E2F4 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher E2F4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated E2F4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where E2F4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	1.000	0.872	.017	18	view →
GBM	OS	Median	All	0.621	0.428	.004	16	view →
LSCC	DFS	Tertile	All	0.715	0.914	.002	14	view →
HNSC	DFS	Median	III,IV	0.355	0.886	.021	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: E2F4 tumor-vs-normal RNA expression · all E2F4 data types