Across TCGA patient cohorts, E2F4 protein abundance is significantly associated with the RNA expression of many other genes, with 5,116 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible E2F4-associated genes across cancer lineages are COG4, DDX19A, and TANGO6. Each is linked with E2F4 in more than 3 cancer types. Because this analysis shows association rather than direction, both E2F4-to-partner and partner-to-E2F4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F4→partner) and Y-score (partner→E2F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COG4 →	+0.476	+0.197	<.001	<.001	3	4
LSCC	DDX19A →	+0.358	+0.186	<.001	<.001	3	3
UCEC	TANGO6 →	+0.522	+0.283	<.001	<.001	3	3
CCRCC	LRCH1 →	+0.408	+0.262	<.001	.002	3	3
CCRCC	CENPC →	+0.428	+0.333	<.001	<.001	3	3
LSCC	GLUD1 →	+0.387	+0.186	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,116 associations by consensus.

Exploration

E2F4 survival (RNA) · tumor vs normal (RNA) · all E2F4 data types