Across TCGA patient cohorts, E2F4 mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F4-associated genes across cancer lineages are RN7SKP289, RNU6-1156P, and SIGLEC27P. Each is linked with E2F4 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F4-to-partner and partner-to-E2F4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F4→partner) and Y-score (partner→E2F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SKP289 →	+0.123	+5.584	<.001	.002	3	2
UCEC	RNU6-1156P →	+0.435	+2.608	<.001	.001	3	2
COAD	SIGLEC27P →	+0.052	+4.070	.002	.009	3	2
UCEC	MIR6515 →	+0.251	+3.335	<.001	.004	3	1
UCEC	SPDYE20P →	+0.198	+2.396	.001	.003	3	1
HNSC	OR5K1 →	+0.043	+5.655	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

Exploration

E2F4 survival (RNA) · tumor vs normal (RNA) · all E2F4 data types