Across TCGA patient cohorts, E2F4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible E2F4-associated genes across cancer lineages are Rad50, MEK1, and Notch1. Each is linked with E2F4 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F4-to-partner and partner-to-E2F4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F4→partner) and Y-score (partner→E2F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.256	-2.584	.023	.011	3	2
UCEC	MEK1 →	+0.563	+2.584	<.001	.011	3	1
UCEC	Notch1 →	+0.184	+2.179	.005	.034	3	1
UCEC	PDK1_pS241 →	+0.160	+3.026	.045	.018	3	1
UCEC	VEGFR2 →	+0.324	+2.179	.019	.034	3	1
UCEC	C-Raf →	+0.194	+2.459	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

E2F4 survival (RNA) · tumor vs normal (RNA) · all E2F4 data types