Across TCGA cell cohorts, E2F4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,014 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible E2F4-associated GO terms across cancer lineages are mRNA alternative polyadenylation, RNA localization, and RNA export from nucleus. Each is linked with E2F4 in more than 15 cancer types. Because this analysis shows association rather than direction, both E2F4-to-partner and partner-to-E2F4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F4→partner) and Y-score (partner→E2F4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	mRNA alternative polyadenylation →	+0.106	+0.881	<.001	.003	3	16
UPPER_AERODIGESTIVE_TRACT	RNA localization →	+0.114	+0.976	<.001	<.001	3	16
BONE	RNA export from nucleus →	+0.174	+0.748	<.001	.003	3	16
BONE	Replication fork processing →	+0.158	+0.793	<.001	<.001	3	15
BONE	Telomere organization →	+0.116	+0.957	<.001	<.001	3	15
BONE	Nucleic acid transport →	+0.160	+0.835	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,014 associations by consensus.

Exploration

E2F4 survival (RNA) · tumor vs normal (RNA) · all E2F4 data types