E2F2

Across TCGA cell cohorts, E2F2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,615 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F2-associated GO terms across cancer lineages are DNA strand elongation involved in DNA replication, DNA-templated DNA replication maintenance of fidelity, and Mitotic DNA replication. Each is linked with E2F2 in more than 19 cancer types. Because this analysis shows association rather than direction, both E2F2-to-partner and partner-to-E2F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation involved in DNA replication grouped by E2F2-low versus E2F2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F2→partner) and Y-score (partner→E2F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation involved in DNA replication →	+0.189	+1.409	<.001	<.001	3	20
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.116	+1.165	<.001	<.001	3	20
BONE	Mitotic DNA replication →	+0.171	+1.541	<.001	<.001	3	19
BONE	Replication fork processing →	+0.110	+1.599	<.001	<.001	3	19
OESOPHAGUS	DNA integrity checkpoint signaling →	+0.095	+1.539	<.001	<.001	3	19
OESOPHAGUS	Regulation of chromosome condensation →	+0.174	+1.201	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,615 associations by consensus.

DNA strand elongation involved in DNA replication by E2F2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →