E2F2

Across TCGA cell cohorts, E2F2 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible E2F2-associated genes across cancer lineages are GZMK, LCN9, and OR2V2. Each is linked with E2F2 in more than 1 cancer types. Because this analysis shows association rather than direction, both E2F2-to-partner and partner-to-E2F2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by E2F2-low versus E2F2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (E2F2→partner) and Y-score (partner→E2F2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GZMK →	+0.042	+4.781	<.001	<.001	3	1
OVARY	LCN9 →	+0.020	+4.222	<.001	.006	3	1
OVARY	OR2V2 →	+0.037	+4.444	<.001	.001	3	1
OVARY	TMCO2 →	+0.085	+3.691	.001	.009	3	1
BLOOD_Leukemia	GCG →	+0.275	+3.643	.001	.006	3	1
BLOOD_Leukemia	GUCA1C →	+0.019	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GZMK by E2F2 expression — OVARY

Explore this box plot interactively →