DZIP1

Across TCGA cell cohorts, DZIP1 mutation is significantly associated with the RNA expression of many other genes, with 594 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DZIP1-associated genes across cancer lineages are NEIL2, HSCB, and GNPNAT1. Each is linked with DZIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DZIP1-to-partner and partner-to-DZIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEIL2 grouped by DZIP1-low versus DZIP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DZIP1→partner) and Y-score (partner→DZIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NEIL2 →	+0.774	+2.459	<.001	.006	3	2
LARGE_INTESTINE	HSCB →	+0.540	+3.459	.001	<.001	3	1
LARGE_INTESTINE	GNPNAT1 →	+0.659	+4.036	<.001	<.001	3	1
LARGE_INTESTINE	DDHD1 →	+0.712	+2.850	.001	<.001	3	1
LARGE_INTESTINE	PPP4R3A →	+0.518	+2.936	<.001	<.001	3	1
LARGE_INTESTINE	RAB5IF →	-0.526	-2.459	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 594 associations by consensus.

NEIL2 by DZIP1 expression — LARGE_INTESTINE

Explore this box plot interactively →