DZANK1

Across TCGA patient cohorts, DZANK1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DZANK1-associated genes across cancer lineages are eEF2, FoxM1, and JNK_pT183_Y185. Each is linked with DZANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DZANK1-to-partner and partner-to-DZANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DZANK1-low versus DZANK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DZANK1→partner) and Y-score (partner→DZANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.293	+2.584	.028	.010	3	2
UCEC	FoxM1 →	+0.199	+1.765	.040	.014	3	2
UCEC	JNK_pT183_Y185 →	-0.189	-2.321	.002	.005	3	2
UCEC	JNK2 →	+0.238	+2.026	.001	.016	3	2
UCEC	mTOR_pS2448 →	-0.117	-1.861	.036	.049	3	2
UCEC	PCNA →	+0.270	+2.222	<.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by DZANK1 expression — UCEC

Explore this box plot interactively →