DZANK1

Across TCGA cell cohorts, DZANK1 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DZANK1-associated genes across cancer lineages are PROP1, BTBD17, and IZUMO3. Each is linked with DZANK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DZANK1-to-partner and partner-to-DZANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by DZANK1-low versus DZANK1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DZANK1→partner) and Y-score (partner→DZANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PROP1 →	+0.030	+4.906	<.001	.006	3	2
BLOOD_Leukemia	BTBD17 →	+0.105	+3.906	<.001	.003	3	2
PANCREAS	IZUMO3 →	+0.267	+4.652	<.001	<.001	3	2
PANCREAS	SPEM3 →	+0.064	+4.222	<.001	.002	3	2
OESOPHAGUS	MMP27 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	FSHR →	+0.013	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PROP1 by DZANK1 expression — OESOPHAGUS

Explore this box plot interactively →