DYSF

Across TCGA pan-cancer cohorts, DYSF Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated DYSF data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher DYSF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DYSF expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCEC, and KIRC are the cancer types where DYSF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.967	<.001	39	view →
UCEC	DFS	Median	All	0.796	0.623	<.001	36	view →
KIRC	DFS	Median	All	0.180	0.796	.001	30	view →
LUSC	DFS	Median	III,IV	0.398	0.683	.007	23	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LIHC	DFS	Median	All	0.160	0.563	<.001	11	view →
ESCA	DFS	Median	II,III,IV	0.152	0.525	.012	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LGG	DFS	Median	All	0.427	0.828	.023	3	view →
SKCM	OS	Median	All	0.930	0.856	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

DYSF–THYM (OS)

Open the THYM breakdown →