DYRK4

Across TCGA patient cohorts, DYRK4 protein abundance is significantly associated with the RNA expression of many other genes, with 863 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DYRK4-associated genes across cancer lineages are SEPTIN3, IDH3B, and FGD1. Each is linked with DYRK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK4-to-partner and partner-to-DYRK4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYRK4 versus SEPTIN3 in CCRCC, with a Pearson correlation of -0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK4→partner) and Y-score (partner→DYRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEPTIN3 →	-0.434	-0.246	.001	.001	3	1
CCRCC	IDH3B →	+0.194	+0.209	.006	.001	3	1
CCRCC	FGD1 →	-0.549	-0.279	<.001	<.001	3	1
CCRCC	NDFIP2 →	+0.402	+0.228	.004	.009	3	1
CCRCC	SLC39A14 →	+0.866	+0.236	<.001	<.001	3	1
CCRCC	C19orf53 →	+0.200	+0.174	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 863 associations by consensus.

DYRK4 vs SEPTIN3 — CCRCC

Explore this scatter interactively →