DYRK4

Across TCGA patient cohorts, DYRK4 mutation is significantly associated with the RNA expression of many other genes, with 3,150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK4-associated genes across cancer lineages are RNU6-290P, CEACAMP11, and GLUD1P4. Each is linked with DYRK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DYRK4-to-partner and partner-to-DYRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-290P grouped by DYRK4-low versus DYRK4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK4→partner) and Y-score (partner→DYRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-290P →	+0.085	+2.966	<.001	.007	3	4
HNSC	CEACAMP11 →	+0.196	+4.141	.006	.001	3	3
HNSC	GLUD1P4 →	+0.158	+3.310	<.001	.009	3	3
HNSC	MIR6515 →	+0.321	+4.810	<.001	.003	3	3
HNSC	RNU2-47P →	+0.112	+4.146	<.001	.008	3	3
HNSC	OR11M1P →	+0.157	+3.314	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,150 associations by consensus.

RNU6-290P by DYRK4 expression — SKCM

Explore this box plot interactively →