DYRK4

Across TCGA cell cohorts, DYRK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,103 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DYRK4-associated GO terms across cancer lineages are Negative regulation of stress-activated protein kinase signaling cascade, Regulation of action potential, and Ionotropic glutamate receptor signaling pathway. Each is linked with DYRK4 in more than 6 cancer types. Because this analysis shows association rather than direction, both DYRK4-to-partner and partner-to-DYRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of stress-activated protein kinase signaling cascade grouped by DYRK4-low versus DYRK4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK4→partner) and Y-score (partner→DYRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of stress-activated protein kinase signaling cascade →	+0.059	+0.852	.001	<.001	3	7
PANCREAS	Regulation of action potential →	-0.135	-0.976	<.001	.001	2	6
BLOOD_Leukemia	Ionotropic glutamate receptor signaling pathway →	-0.148	-1.040	<.001	<.001	3	5
STOMACH	Cardiac ventricle development →	-0.103	-1.354	.002	.007	3	5
BONE	DNA modification →	+0.073	+0.604	.004	.004	3	5
OESOPHAGUS	Cellular response to unfolded protein →	+0.078	+1.200	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,103 associations by consensus.

Negative regulation of stress-activated protein kinase signaling cascade by DYRK4 expression — BLOOD_Leukemia

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