DYRK4

Across TCGA cell cohorts, DYRK4 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYRK4-associated genes across cancer lineages are OR1L3, C5orf52, and C1orf158. Each is linked with DYRK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK4-to-partner and partner-to-DYRK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by DYRK4-low versus DYRK4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK4→partner) and Y-score (partner→DYRK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	1
SKIN	C5orf52 →	+0.041	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	C1orf158 →	+0.069	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	WFDC8 →	+0.010	+3.604	<.001	.004	3	1
LARGE_INTESTINE	CUEDC2 →	+0.755	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PDS5A →	+0.626	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

OR1L3 by DYRK4 expression — SKIN

Explore this box plot interactively →