DYRK3

Across TCGA patient cohorts, DYRK3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK3-associated genes across cancer lineages are ASNS, Cyclin-B1, and ATM. Each is linked with DYRK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK3-to-partner and partner-to-DYRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DYRK3-low versus DYRK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK3→partner) and Y-score (partner→DYRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.272	+2.584	.045	.010	3	3
COAD	Cyclin-B1 →	+0.630	+3.008	.025	.019	3	2
UCEC	ATM →	-0.410	-2.446	.015	.018	3	2
COAD	FASN →	+0.694	+3.008	<.001	.019	3	1
COAD	MYH11 →	-1.630	-3.000	.015	.035	3	1
COAD	PREX1 →	+0.276	+2.820	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ASNS by DYRK3 expression — UCEC

Explore this box plot interactively →