DYRK3

Across TCGA cell cohorts, DYRK3 mutation is significantly associated with the RNA expression of many other genes, with 44 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DYRK3-associated genes across cancer lineages are NOP53, BAAT, and KLKB1. Each is linked with DYRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK3-to-partner and partner-to-DYRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP53 grouped by DYRK3-low versus DYRK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK3→partner) and Y-score (partner→DYRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOP53 →	+0.637	+3.064	.002	.009	3	1
LARGE_INTESTINE	BAAT →	+0.361	+3.465	.001	.002	3	1
LARGE_INTESTINE	KLKB1 →	+0.344	+3.389	.001	.007	3	1
LARGE_INTESTINE	NT5M →	+1.159	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CELA3B →	+0.140	+2.855	.007	.005	3	1
LARGE_INTESTINE	RNF148 →	+0.331	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

NOP53 by DYRK3 expression — LARGE_INTESTINE

Explore this box plot interactively →