DYRK1B

Across TCGA patient cohorts, DYRK1B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYRK1B-associated genes across cancer lineages are GAPDH, FoxM1, and p62 Lck ligand. Each is linked with DYRK1B in more than 2 cancer types. Because this analysis shows association rather than direction, both DYRK1B-to-partner and partner-to-DYRK1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by DYRK1B-low versus DYRK1B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1B→partner) and Y-score (partner→DYRK1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.589	+2.820	.025	.035	3	3
UCEC	FoxM1 →	+0.190	+2.000	.037	.003	3	3
UCEC	p62 Lck ligand →	+0.444	+3.700	<.001	.001	3	2
UCEC	ASNS →	+0.386	+1.807	.002	.025	3	2
UCEC	eIF4E →	+0.155	+2.000	.037	.003	3	1
UCEC	Fibronectin →	-0.238	-1.662	.041	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

GAPDH by DYRK1B expression — COAD

Explore this box plot interactively →