DYRK1B

Across TCGA cell cohorts, DYRK1B mutation is significantly associated with the RNA expression of many other genes, with 233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DYRK1B-associated genes across cancer lineages are ASB10, ARHGAP36, and SLC35G3. Each is linked with DYRK1B in more than 1 cancer types. Because this analysis shows association rather than direction, both DYRK1B-to-partner and partner-to-DYRK1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB10 grouped by DYRK1B-low versus DYRK1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYRK1B→partner) and Y-score (partner→DYRK1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASB10 →	+0.104	+3.551	<.001	.009	3	1
BLOOD_Leukemia	ARHGAP36 →	+0.018	+3.944	<.001	.006	3	1
BLOOD_Leukemia	SLC35G3 →	+0.053	+3.874	<.001	.005	3	1
BLOOD_Leukemia	C16orf92 →	+0.120	+4.037	.006	.004	3	1
BLOOD_Leukemia	TBPL2 →	+0.109	+4.044	<.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.127	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

ASB10 by DYRK1B expression — BLOOD_Leukemia

Explore this box plot interactively →