DYNLT3

Across TCGA patient cohorts, DYNLT3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNLT3-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Heregulin. Each is linked with DYNLT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNLT3-to-partner and partner-to-DYNLT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DYNLT3-low versus DYNLT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNLT3→partner) and Y-score (partner→DYNLT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-2.973	.045	.035	3	1
UCEC	ERK2 →	+0.258	+3.169	.014	.020	3	1
UCEC	Heregulin →	-0.150	-3.000	.027	.036	3	1
UCEC	Tuberin →	+0.352	+3.169	.017	.020	3	1
UCEC	VEGFR2 →	+0.478	+2.817	.003	.036	3	1
UCEC	ASNS →	+0.553	+3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

14-3-3_beta by DYNLT3 expression — UCEC

Explore this box plot interactively →