DYNLRB2

Across TCGA patient cohorts, DYNLRB2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNLRB2-associated genes across cancer lineages are MSH2, Notch1, and Rab25. Each is linked with DYNLRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNLRB2-to-partner and partner-to-DYNLRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by DYNLRB2-low versus DYNLRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNLRB2→partner) and Y-score (partner→DYNLRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.396	-2.973	.001	.035	3	1
UCEC	Notch1 →	+0.267	+2.817	<.001	.036	3	1
UCEC	Rab25 →	-0.584	-3.169	.001	.020	3	1
UCEC	p70-S6K_pT389 →	-0.207	-3.169	.047	.020	2	1
UCEC	EGFR_pY1068 →	-0.282	-3.169	.040	.020	1	1
UCEC	p21 →	+0.262	+3.169	.012	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MSH2 by DYNLRB2 expression — UCEC

Explore this box plot interactively →