DYNLRB1

Across TCGA pan-cancer cohorts, DYNLRB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DYNLRB1 data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DYNLRB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYNLRB1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where DYNLRB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.890	0.686	.003	13	view →
GBM	OS	Quartile	All	0.238	0.672	.001	12	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	7	view →
OV	DFS	Median	All	0.868	1.000	.040	4	view →
UCEC	DFS	Median	All	1.000	0.941	.036	2	view →
LSCC	OS	Median	All	0.793	1.000	.025	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DYNLRB1–HNSC (DFS)

Open the HNSC breakdown →