DYNLRB1

Across TCGA patient cohorts, DYNLRB1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNLRB1-associated genes across cancer lineages are Heregulin, Annexin-1, and SCD. Each is linked with DYNLRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNLRB1-to-partner and partner-to-DYNLRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by DYNLRB1-low versus DYNLRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNLRB1→partner) and Y-score (partner→DYNLRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.170	-3.000	.012	.036	3	1
UCEC	Annexin-1 →	+0.733	+2.827	.011	.035	3	1
UCEC	SCD →	-0.152	-3.156	.011	.020	3	1
UCEC	SF2 →	-0.155	-3.156	.009	.020	3	1
UCEC	Tuberin →	+0.336	+3.169	.023	.020	3	1
UCEC	ATM →	-0.676	-3.169	.006	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Heregulin by DYNLRB1 expression — UCEC

Explore this box plot interactively →