DYNLL2

Across TCGA pan-cancer cohorts, DYNLL2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DYNLL2 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DYNLL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DYNLL2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and PDAC are the cancer types where DYNLL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.819	0.535	.020	19	view →
COAD	DFS	Quartile	II,III,IV	1.000	0.896	.046	12	view →
PDAC	DFS	Quartile	All	0.639	0.349	.011	10	view →
LSCC	DFS	Tertile	III,IV	0.540	1.000	.035	10	view →
LUAD	DFS	Quartile	All	0.881	0.362	.001	7	view →
GBM	OS	Tertile	All	0.533	0.279	.017	4	view →
UCEC	DFS	Tertile	All	0.922	0.733	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DYNLL2–CCRCC (DFS)

Open the CCRCC breakdown →