DYNLL2

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DYNLL2 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNLL2-associated genes across cancer lineages are CD8+ Tcm and Fibroblasts. Each is linked with DYNLL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNLL2-to-partner and partner-to-DYNLL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by DYNLL2-low versus DYNLL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNLL2→partner) and Y-score (partner→DYNLL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCD8+ Tcm →+0.031+2.935.025.04631
UCECFibroblasts →+0.053+3.393<.001.00731
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ Tcm by DYNLL2 expression — UCEC

Box plot of CD8+ Tcm in DYNLL2-low vs DYNLL2-high samples in UCEC.

Explore this box plot interactively →

Exploration