DYNLL1

Across TCGA pan-cancer cohorts, DYNLL1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DYNLL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DYNLL1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DYNLL1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, PDAC, and LSCC are the cancer types where DYNLL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DYNLL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.184	<.001	8	view →
PDAC	All	All	−0.225	.001	5	view →
LSCC	Male	II,III,IV	+0.196	<.001	4	view →
LUAD	Female	All	−0.210	<.001	3	view →
CCRCC	Male	III,IV	+0.156	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DYNLL1–COAD

Open the COAD breakdown →