DYNLL1

Across TCGA cell cohorts, DYNLL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,747 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DYNLL1-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, Positive regulation of mitotic metaphase/anaphase transition, and Negative regulation of mitotic spindle assembly checkpoint signaling. Each is linked with DYNLL1 in more than 8 cancer types. Because this analysis shows association rather than direction, both DYNLL1-to-partner and partner-to-DYNLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by DYNLL1-low versus DYNLL1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNLL1→partner) and Y-score (partner→DYNLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of ubiquitin protein ligase activity →	+0.125	+0.428	<.001	<.001	3	9
BREAST	Positive regulation of mitotic metaphase/anaphase transition →	+0.085	+0.344	.001	.004	3	9
CNS	Negative regulation of mitotic spindle assembly checkpoint signaling →	+0.168	+0.694	<.001	<.001	3	9
CNS	Negative regulation of spindle checkpoint →	+0.168	+0.694	<.001	<.001	3	9
LIVER	Protein-RNA covalent cross-linking repair →	+0.160	+0.509	<.001	.001	3	9
BLOOD_Lymphoma	Regulation of mitotic nuclear division →	+0.064	+0.538	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,747 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by DYNLL1 expression — BREAST

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