DYNC2LI1

Across TCGA patient cohorts, DYNC2LI1 mutation is significantly associated with the RNA expression of many other genes, with 2,037 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC2LI1-associated genes across cancer lineages are OR6N1, RN7SKP61, and UGT1A6. Each is linked with DYNC2LI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2LI1-to-partner and partner-to-DYNC2LI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6N1 grouped by DYNC2LI1-low versus DYNC2LI1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2LI1→partner) and Y-score (partner→DYNC2LI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	OR6N1 →	+0.046	+4.757	<.001	.004	3	2
HNSC	RN7SKP61 →	+0.159	+7.954	<.001	.008	3	2
SKCM	UGT1A6 →	+0.148	+3.805	<.001	.009	3	2
SKCM	HSPE1P13 →	+0.258	+3.801	<.001	.007	3	2
UCEC	MIA-RAB4B →	+0.066	+1.622	<.001	.008	3	2
UCEC	IGKV1-37 →	+0.101	+2.038	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,037 associations by consensus.

OR6N1 by DYNC2LI1 expression — CESC

Explore this box plot interactively →