DYNC2LI1

Across TCGA patient cohorts, DYNC2LI1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC2LI1-associated genes across cancer lineages are FASN, HER3_pY1289, and Acetyl-a-Tubulin-Lys40. Each is linked with DYNC2LI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2LI1-to-partner and partner-to-DYNC2LI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by DYNC2LI1-low versus DYNC2LI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2LI1→partner) and Y-score (partner→DYNC2LI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.372	+3.169	.010	.018	3	2
UCEC	HER3_pY1289 →	+0.077	+1.604	.015	.042	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.556	+2.736	.002	<.001	3	2
UCEC	Ku80 →	+0.251	+1.861	.003	.005	3	2
UCEC	Notch1 →	+0.258	+2.736	<.001	<.001	3	2
UCEC	ASNS →	+0.428	+2.222	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

FASN by DYNC2LI1 expression — UCEC

Explore this box plot interactively →