DYNC2LI1

Across TCGA cell cohorts, DYNC2LI1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DYNC2LI1-associated genes across cancer lineages are GSG1L2, SLC22A9, and INSL5. Each is linked with DYNC2LI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2LI1-to-partner and partner-to-DYNC2LI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by DYNC2LI1-low versus DYNC2LI1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2LI1→partner) and Y-score (partner→DYNC2LI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
SKIN	SLC22A9 →	+0.028	+4.273	<.001	.006	3	1
SKIN	INSL5 →	+0.053	+4.467	<.001	.004	3	1
SKIN	XCR1 →	+0.192	+4.273	<.001	.006	3	1
SKIN	C2CD4B →	+0.062	+4.684	<.001	.002	3	1
SKIN	TMEM114 →	+0.048	+5.562	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GSG1L2 by DYNC2LI1 expression — LARGE_INTESTINE

Explore this box plot interactively →