DYNC2I2

Across TCGA pan-cancer cohorts, DYNC2I2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DYNC2I2 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher DYNC2I2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DYNC2I2 expression acts as an unfavorable survival marker.

BRCA, HNSC, and OV are the cancer types where DYNC2I2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.113	0.578	.001	24	view →
HNSC	DFS	Median	All	0.131	0.627	.003	24	view →
OV	DFS	Median	II,III,IV	0.140	0.541	.001	18	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
CESC	OS	Median	II,III,IV	0.227	0.759	.029	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	DFS	Median	All	0.238	0.699	.003	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DYNC2I2–BRCA (OS)

Open the BRCA breakdown →