DYNC2I2

Across TCGA patient cohorts, DYNC2I2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,562 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DYNC2I2-associated genes across cancer lineages are RIBC1, OSCP1, and TTC25. Each is linked with DYNC2I2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DYNC2I2-to-partner and partner-to-DYNC2I2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DYNC2I2 versus RIBC1 in UCEC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I2→partner) and Y-score (partner→DYNC2I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RIBC1 →	+1.001	+0.356	<.001	<.001	3	5
UCEC	OSCP1 →	+0.831	+0.337	<.001	<.001	3	4
UCEC	TTC25 →	+1.060	+0.307	<.001	<.001	3	4
UCEC	RN7SKP24 →	+1.514	+0.374	<.001	<.001	3	4
UCEC	RSPH14 →	+0.684	+0.304	<.001	<.001	3	3
BRCA	SAMD15 →	+1.022	+0.301	<.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,562 associations by consensus.

DYNC2I2 vs RIBC1 — UCEC

Explore this scatter interactively →