DYNC2I2

Across TCGA patient cohorts, DYNC2I2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DYNC2I2-associated genes across cancer lineages are PCNA, ERK2, and FOXO3a_pS318_S321. Each is linked with DYNC2I2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DYNC2I2-to-partner and partner-to-DYNC2I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DYNC2I2-low versus DYNC2I2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I2→partner) and Y-score (partner→DYNC2I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.238	+2.459	.018	.019	3	2
UCEC	ERK2 →	+0.217	+3.321	.015	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.312	.015	.034	3	1
UCEC	mTOR_pS2448 →	-0.148	-3.150	.033	.019	3	1
UCEC	p27 →	+0.245	+3.169	.016	.019	3	1
UCEC	p62 Lck ligand →	+0.339	+2.469	.025	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by DYNC2I2 expression — UCEC

Explore this box plot interactively →