DYNC2I2

Across TCGA cell cohorts, DYNC2I2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,391 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DYNC2I2-associated GO terms across cancer lineages are Regulation of cell cycle checkpoint, CTP salvage, and Meiotic chromosome condensation. Each is linked with DYNC2I2 in more than 15 cancer types. Because this analysis shows association rather than direction, both DYNC2I2-to-partner and partner-to-DYNC2I2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell cycle checkpoint grouped by DYNC2I2-low versus DYNC2I2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DYNC2I2→partner) and Y-score (partner→DYNC2I2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of cell cycle checkpoint →	+0.071	+1.121	<.001	<.001	3	16
SOFT_TISSUE	CTP salvage →	+0.126	+1.194	<.001	<.001	3	15
SOFT_TISSUE	Meiotic chromosome condensation →	+0.190	+1.357	<.001	<.001	3	15
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.207	+1.588	<.001	<.001	3	15
PANCREAS	Spindle midzone assembly →	+0.216	+1.017	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Spindle elongation →	+0.261	+1.294	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,391 associations by consensus.

Regulation of cell cycle checkpoint by DYNC2I2 expression — SKIN

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